InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSPO

Summary

InnateDB Protein

IDBP-10474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSPO

Protein Name

translocator protein (18kDa)

Synonyms

BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR;

Species

Homo sapiens

Ensembl Protein

ENSP00000328973

InnateDB Gene

IDBG-10470 (TSPO)

Protein Structure

UniProt Annotation

Function

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides(PubMed:1847678). {ECO:0000250, ECO:0000269PubMed:1847678, ECO:0000269PubMed:24814875}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:1847678}; Multi-pass membrane protein {ECO:0000269PubMed:1847678}.

Disease Associations

Tissue Specificity

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. {ECO:0000269PubMed:20600583}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015485	cholesterol binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006783	heme biosynthetic process
GO:0006820	anion transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0008202	steroid metabolic process
GO:0008283	cell proliferation
GO:0032374	regulation of cholesterol transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome