InnateDB Protein
|
IDBP-104892.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CENPL
|
Protein Name
|
centromere protein L
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000323543
|
InnateDB Gene
|
IDBG-104888 (CENPL)
|
Protein Structure
|
|
Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:16716197}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:16716197}. Chromosome, centromere {ECO:0000269PubMed:16716197}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8N0S6
|
PhosphoSite |
PhosphoSite-Q8N0S6
|
TrEMBL |
A0A024R932
|
UniProt Splice Variant |
|
Entrez Gene |
91687
|
UniGene |
Hs.720473
|
RefSeq |
NP_001164653
|
HUGO |
HGNC:17879
|
OMIM |
611503
|
CCDS |
CCDS30938
|
HPRD |
15909
|
IMGT |
|
EMBL |
AK055606
AL109921
BC007071
BC033154
BC066658
CH471067
|
GenPept |
AAH07071
AAH33154
AAH66658
BAB70968
CAI20378
CAI20379
EAW90956
EAW90957
EAW90959
|
|
|