InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DARS2

Summary

InnateDB Protein

IDBP-104903.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DARS2

Protein Name

aspartyl-tRNA synthetase 2, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355086

InnateDB Gene

IDBG-104901 (DARS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:15779907}.

Disease Associations

Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) [MIM:611105]: Autosomal recessive disease and is defined on the basis of a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy. Affected individuals develop slowly progressive cerebellar ataxia, spasticity, and dorsal column dysfunction, sometimes with a mild cognitive deficit or decline. {ECO:0000269PubMed:17384640}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004815	aspartate-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0050560	aspartate-tRNA(Asn) ligase activity

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0010467	gene expression
GO:0043039	tRNA aminoacylation
GO:0070145	mitochondrial asparaginyl-tRNA aminoacylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR004115 GAD-like domain
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR004524 Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR012340 Nucleic acid-binding, OB-fold
IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
IPR029351 GAD domain

PFAM

PF00152
PF01336
PF02938

PRINTS

PR01042
PR00982

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PI48