InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNR

Summary

InnateDB Protein

IDBP-104983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNR

Protein Name

tenascin R (restrictin, janusin)

Synonyms

TN-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000356646

InnateDB Gene

IDBG-104981 (TNR)

Protein Structure

UniProt Annotation

Function

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Brain specific. {ECO:0000269PubMed:8626505}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007411	axon guidance
GO:0008306	associative learning
GO:0010977	negative regulation of neuron projection development
GO:0022029	telencephalon cell migration
GO:0022408	negative regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030517	negative regulation of axon extension
GO:0035641	locomotory exploration behavior
GO:0048692	negative regulation of axon extension involved in regeneration
GO:0050804	regulation of synaptic transmission
GO:0050805	negative regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0045121	membrane raft
GO:0072534	perineuronal net

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR003961 Fibronectin, type III
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF00147
PF00041
PF01108
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00186
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92752