InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAPPA2

Summary

InnateDB Protein

IDBP-105010.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPPA2

Protein Name

pappalysin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356633

InnateDB Gene

IDBG-105006 (PAPPA2)

Protein Structure

UniProt Annotation

Function

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. {ECO:0000269PubMed:11264294}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269PubMed:11264294, ECO:0000269PubMed:11597188}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006508	proteolysis
GO:0030154	cell differentiation
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000800 Notch domain
IPR001791 Laminin G domain
IPR006558 LamG-like jellyroll fold
IPR008754 Peptidase M43, pregnancy-associated plasma-A
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00066
PF00054
PF02210
PF05572

PRINTS

PR01452

PIRSF

SMART

SM00004
SM00210
SM00282
SM00560

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt