InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QSOX1

Summary

InnateDB Protein

IDBP-105165.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QSOX1

Protein Name

quiescin Q6 sulfhydryl oxidase 1

Synonyms

Q6; QSCN6;

Species

Homo sapiens

Ensembl Protein

ENSP00000356572

InnateDB Gene

IDBG-105161 (QSOX1)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. {ECO:0000269PubMed:10542195, ECO:0000269PubMed:10708601, ECO:0000269PubMed:12176051, ECO:0000269PubMed:16806532, ECO:0000269PubMed:17331072, ECO:0000269PubMed:18393449}.

Subcellular Localization

Isoform 1: Golgi apparatus membrane; Single- pass membrane protein.Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Disease Associations

Tissue Specificity

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. {ECO:0000269PubMed:10708601, ECO:0000269Ref.9}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0016971	flavin-linked sulfhydryl oxidase activity
GO:0016972	thiol oxidase activity