InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MR1

Summary

InnateDB Protein

IDBP-105199.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MR1

Protein Name

major histocompatibility complex, class I-related

Synonyms

HLALS;

Species

Homo sapiens

Ensembl Protein

ENSP00000356551

InnateDB Gene

IDBG-105193 (MR1)

Protein Structure

UniProt Annotation

Function

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. {ECO:0000269PubMed:12794138, ECO:0000269PubMed:19416870}.

Subcellular Localization

Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.Isoform 4: Secreted.Isoform 3: Cell membrane {ECO:0000269PubMed:23457030}; Single-pass type I membrane protein {ECO:0000269PubMed:23457030}. Endoplasmic reticulum membrane {ECO:0000269PubMed:23457030}. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:7624800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032393	MHC class I receptor activity
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019882	antigen processing and presentation
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0042612	MHC class I protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00129
PF07654

PRINTS

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q95460