InnateDB Protein
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IDBP-105260.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS8
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Protein Name
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regulator of G-protein signaling 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000258302
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InnateDB Gene
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IDBG-105256 (RGS8)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
P57771
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
85397
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UniGene |
Hs.458417
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RefSeq |
NP_203131
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HUGO |
HGNC:16810
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OMIM |
607189
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CCDS |
CCDS1349
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HPRD |
06221
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IMGT |
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EMBL |
AF297015
AF300649
AK294660
AK296514
AL353778
BC069677
BC069718
BC103865
BC103866
BC103867
CH471067
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GenPept |
AAG18443
AAG45337
AAH69677
AAH69718
AAI03866
AAI03867
AAI03868
BAG57830
BAG59146
CAH72421
EAW91130
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