InnateDB Protein
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IDBP-105267.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NPL
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Protein Name
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N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356526
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InnateDB Gene
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IDBG-105265 (NPL)
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Protein Structure
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Function |
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. {ECO:0000269PubMed:16147865}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002220
DapA-like
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PFAM |
PF00701
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PRINTS |
PR00146
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PIRSF |
PIRSF001365
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXD5
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PhosphoSite |
PhosphoSite-Q9BXD5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80896
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UniGene |
Hs.596206
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RefSeq |
NP_001186980
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HUGO |
HGNC:16781
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OMIM |
611412
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CCDS |
CCDS55666
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HPRD |
14836
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IMGT |
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EMBL |
AF338436
AK313225
AL355999
AL513344
AY336748
BC034966
BC042003
BC058003
BC125051
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GenPept |
AAH58003
AAI25052
AAK25795
AAQ82432
BAG36036
CAH71702
CAH71703
CAI16502
CAI16503
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