Version 5.4
| Homo sapiens Gene: NPL | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105265.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | NPL | ||||||||||||||||||
| Gene Name | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000135838 | ||||||||||||||||||
| Encoded Proteins |
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:182789293-182830384 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q25.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
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| KEGG |
Amino sugar and nucleotide sugar metabolism pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.496969 Hs.596206 | ||||||||||||||||||
| RefSeq | NM_001200050 NM_001200051 NM_001200052 NM_001200056 NM_030769 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS1350 CCDS55666 CCDS55667 CCDS72990 | ||||||||||||||||||
| HPRD | 14836 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||