Version 5.4
Homo sapiens Protein: NPL
Summary
InnateDB Protein IDBP-105273.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPL
Protein Name N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356523
InnateDB Gene IDBG-105265 (NPL)
Protein Structure
UniProt Annotation
Function Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. {ECO:0000269PubMed:16147865}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008747 N-acetylneuraminate lyase activity
GO:0016829 lyase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
GO:0019262 N-acetylneuraminate catabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002220 DapA-like
PFAM PF00701
PRINTS PR00146
PIRSF PIRSF001365
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXD5
PhosphoSite PhosphoSite-Q9BXD5
TrEMBL
UniProt Splice Variant
Entrez Gene 80896
UniGene Hs.596206
RefSeq
HUGO HGNC:16781
OMIM 611412
CCDS CCDS55666
HPRD 14836
IMGT
EMBL AF338436 AK313225 AL355999 AL513344 AY336748 BC034966 BC042003 BC058003 BC125051
GenPept AAH58003 AAI25052 AAK25795 AAQ82432 BAG36036 CAH71702 CAH71703 CAI16502 CAI16503

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca