InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCF2

Summary

InnateDB Protein

IDBP-105314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCF2

Protein Name

neutrophil cytosolic factor 2

Synonyms

NCF-2; NOXA2; P67-PHOX; P67PHOX;

Species

Homo sapiens

Ensembl Protein

ENSP00000356506

InnateDB Gene

IDBG-105312 (NCF2)

Protein Structure

UniProt Annotation

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269PubMed:12207919}.

Subcellular Localization

Cytoplasm.

Disease Associations

Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2) [MIM:233710]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269PubMed:10498624, ECO:0000269PubMed:10598813, ECO:0000269PubMed:11112388, ECO:0000269PubMed:16937026, ECO:0000269PubMed:18625437, ECO:0000269PubMed:19624736, ECO:0000269PubMed:20167518, ECO:0000269PubMed:8286749, ECO:0000269PubMed:9070911}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0009055	electron carrier activity

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006801	superoxide metabolic process
GO:0006968	cellular defense response
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0051701	interaction with host
GO:0090382	phagosome maturation

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0032010	phagolysosome
GO:0043020	NADPH oxidase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR001440 Tetratricopeptide TPR1
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM