InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARPC5

Summary

InnateDB Protein

IDBP-105321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC5

Protein Name

actin related protein 2/3 complex, subunit 5, 16kDa

Synonyms

ARC16; dJ127C7.3; p16-Arc;

Species

Homo sapiens

Ensembl Protein

ENSP00000294742

InnateDB Gene

IDBG-105317 (ARPC5)

Protein Structure

UniProt Annotation

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:9230079}. Cell projection {ECO:0000269PubMed:9230079}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0030036	actin cytoskeleton organization
GO:0030833	regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005885	Arp2/3 protein complex
GO:0015629	actin cytoskeleton
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome