InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDEM3

Summary

InnateDB Protein

IDBP-105365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDEM3

Protein Name

ER degradation enhancer, mannosidase alpha-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318147

InnateDB Gene

IDBG-105359 (EDEM3)

Protein Structure

UniProt Annotation

Function

Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004569	glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006457	protein folding
GO:0006516	glycoprotein catabolic process
GO:0006986	response to unfolded protein
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process