Version 5.4
Homo sapiens Gene: EDEM3
Summary
InnateDB Gene IDBG-105359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDEM3
Gene Name ER degradation enhancer, mannosidase alpha-like 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116406
Encoded Proteins
IDBP-105361
ER degradation enhancer, mannosidase alpha-like 3
IDBP-105365
ER degradation enhancer, mannosidase alpha-like 3
IDBP-389805
ER degradation enhancer, mannosidase alpha-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:184690231-184754913
Strand Reverse strand
Band q25.3
Transcripts
ENST00000367512 ENSP00000356482
ENST00000318130 ENSP00000318147
ENST00000439962 ENSP00000390536
ENST00000466392
ENST00000474725
ENST00000466606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006457 protein folding
GO:0006516 glycoprotein catabolic process
GO:0006986 response to unfolded protein
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043019
View Gene Order
ENSBTAG00000019264
Not yet available
Pathways
NETPATH
REACTOME
REACT_25091
ER Quality Control Compartment (ERQC) pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523811 Hs.601234 Hs.604767
RefSeq NM_025191 XM_005245499
HUGO
OMIM
CCDS CCDS1363
HPRD 10724
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca