InnateDB Protein
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IDBP-105458.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UCHL5
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Protein Name
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ubiquitin carboxyl-terminal hydrolase L5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356424
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InnateDB Gene
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IDBG-105454 (UCHL5)
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Protein Structure
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Function |
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269PubMed:16906146, ECO:0000269PubMed:18922472}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18922472}. Nucleus {ECO:0000269PubMed:18922472}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
221
[view]
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Protein-Protein |
220
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006281
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DNA repair
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GO:0006310
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DNA recombination
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0010951
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negative regulation of endopeptidase activity
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GO:0016579
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protein deubiquitination
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GO:0030512
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negative regulation of transforming growth factor beta receptor signaling pathway
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GO:0061136
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regulation of proteasomal protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001578
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
IPR017390
Ubiquitinyl hydrolase, UCH37 type
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PFAM |
PF01088
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PRINTS |
PR00707
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PIRSF |
PIRSF038120
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5K5
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PhosphoSite |
PhosphoSite-Q9Y5K5
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TrEMBL |
B4DKB3
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UniProt Splice Variant |
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Entrez Gene |
51377
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UniGene |
Hs.145469
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RefSeq |
NP_001186190
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HUGO |
HGNC:19678
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OMIM |
610667
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CCDS |
CCDS55668
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HPRD |
10293
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IMGT |
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EMBL |
AF147717
AF151828
AF157320
AK296487
AL136370
BC015521
BC025369
BT006790
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GenPept |
AAD31528
AAD34065
AAF67486
AAH15521
AAH25369
AAP35436
BAG59125
CAI10829
CAI10830
CAI10831
CAI10833
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