Version 5.4
Homo sapiens Protein: UCHL5
Summary
InnateDB Protein IDBP-105470.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL5
Protein Name ubiquitin carboxyl-terminal hydrolase L5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356418
InnateDB Gene IDBG-105454 (UCHL5)
Protein Structure
UniProt Annotation
Function Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269PubMed:16906146, ECO:0000269PubMed:18922472}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18922472}. Nucleus {ECO:0000269PubMed:18922472}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
Experimentally validated
Total 221 [view]
Protein-Protein 220 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0044822 poly(A) RNA binding
GO:0070628 proteasome binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010951 negative regulation of endopeptidase activity
GO:0016579 protein deubiquitination
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031011 Ino80 complex
Protein Structure and Domains
PDB ID
InterPro IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
IPR017390 Ubiquitinyl hydrolase, UCH37 type
PFAM PF01088
PRINTS PR00707
PIRSF PIRSF038120
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5K5
PhosphoSite PhosphoSite-Q9Y5K5
TrEMBL
UniProt Splice Variant
Entrez Gene 51377
UniGene Hs.145469
RefSeq NP_001186191
HUGO HGNC:19678
OMIM 610667
CCDS CCDS55670
HPRD 10293
IMGT
EMBL AF147717 AF151828 AF157320 AL136370 BC015521 BC025369 BT006790
GenPept AAD31528 AAD34065 AAF67486 AAH15521 AAH25369 AAP35436 CAI10829 CAI10830 CAI10831 CAI10833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca