Version 5.4
| Homo sapiens Protein: DENND1B | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-105574.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | DENND1B | ||||
| Protein Name | DENN/MADD domain containing 1B | ||||
| Synonyms | |||||
| Species | Homo sapiens | ||||
| Ensembl Protein | ENSP00000356366 | ||||
| InnateDB Gene | IDBG-246597 (DENND1B) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin- mediated endocytosis. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}. | ||||
| Subcellular Localization | Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. | ||||
| Disease Associations | |||||
| Tissue Specificity | Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells. {ECO:0000269PubMed:20032318}. | ||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | |||||
| InterPro |
IPR001194
DENN domain IPR005112 dDENN domain IPR005113 uDENN domain |
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| PFAM |
PF02141
PF03455 PF03456 |
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| PRINTS | |||||
| PIRSF | |||||
| SMART |
SM00799
SM00801 SM00800 |
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| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q6P3S1 | ||||
| PhosphoSite | PhosphoSite-Q6P3S1 | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 163486 | ||||
| UniGene | Hs.743766 | ||||
| RefSeq | NP_659414 | ||||
| HUGO | HGNC:28404 | ||||
| OMIM | 613292 | ||||
| CCDS | CCDS41452 | ||||
| HPRD | 13303 | ||||
| IMGT | |||||
| EMBL | AK000061 AK024832 AL139136 AL365258 AL831839 BC022561 BC063877 BC074735 BK006960 CH471067 | ||||
| GenPept | AAH22561 AAH63877 AAH74735 BAA90918 BAB15024 CAD38548 CAI14212 CAI14213 CAI14214 CAI15312 CAI15313 CAI15314 CAI15315 DAA12502 EAW91280 EAW91281 EAW91285 | ||||