Version 5.4
Homo sapiens Gene: DENND1B
Summary
InnateDB Gene IDBG-246597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1B
Gene Name DENN/MADD domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213047
Encoded Proteins
IDBP-105572
DENN/MADD domain containing 1B
IDBP-105574
DENN/MADD domain containing 1B
IDBP-105578
DENN/MADD domain containing 1B
IDBP-246599
DENN/MADD domain containing 1B
IDBP-389840
DENN/MADD domain containing 1B
IDBP-807627
DENN/MADD domain containing 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:197504748-197775696
Strand Reverse strand
Band q31.3
Transcripts
ENST00000294737 ENSP00000294737
ENST00000367396 ENSP00000356366
ENST00000294738
ENST00000235453 ENSP00000235453
ENST00000391979 ENSP00000375839
ENST00000422998 ENSP00000410025
ENST00000463124
ENST00000496935
ENST00000468589
ENST00000495550
ENST00000477581
ENST00000620048 ENSP00000479816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0015031 protein transport
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005829 cytosol
GO:0030136 clathrin-coated vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000056268
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.125056 Hs.601260 Hs.605362 Hs.743766
RefSeq NM_001195215 NM_001300858 NM_144977 XM_005244932 XM_005244933 XM_006711192 XM_006711193 XM_006711194
HUGO
OMIM
CCDS CCDS41452 CCDS72996 CCDS72997
HPRD 13303
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca