InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR5A2

Summary

InnateDB Protein

IDBP-105632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR5A2

Protein Name

nuclear receptor subfamily 5, group A, member 2

Synonyms

B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356331

InnateDB Gene

IDBG-105630 (NR5A2)

Protein Structure

UniProt Annotation

Function

Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	33 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008206	bile acid metabolic process
GO:0009790	embryo development
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0031018	endocrine pancreas development
GO:0042127	regulation of cell proliferation
GO:0042592	homeostatic process
GO:0042632	cholesterol homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0045070	positive regulation of viral genome replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR016355 Steroidogenic factor 1

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

PIRSF002530

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References