Version 5.4
Homo sapiens Protein: NAV1
Summary
InnateDB Protein IDBP-105790.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAV1
Protein Name neuron navigator 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356264
InnateDB Gene IDBG-105776 (NAV1)
Protein Structure
UniProt Annotation
Function May be involved in neuronal migration. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta. {ECO:0000269PubMed:12062803, ECO:0000269PubMed:12079279}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEY1
PhosphoSite PhosphoSite-Q8NEY1
TrEMBL
UniProt Splice Variant
Entrez Gene 89796
UniGene Hs.700084
RefSeq NP_001161210
HUGO HGNC:15989
OMIM 611628
CCDS CCDS53456
HPRD 10113
IMGT
EMBL AB032977 AB033039 AC092800 AC096677 AJ251973 AJ488101 AK022622 AK022631 AK024265 AL512788 AL645504 AY043013 BC007523
GenPept AAH07523 AAL05591 BAA86465 BAA86527 BAB14136 BAB14142 BAB14865 CAB66088 CAD32470 CAH71925 CAI17010 CAI17011 CAI17012 CAI17013 CAI17014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca