InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELF3

Summary

InnateDB Protein

IDBP-105814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELF3

Protein Name

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

Synonyms

EPR-1; ERT; ESE-1; ESX;

Species

Homo sapiens

Ensembl Protein

ENSP00000352673

InnateDB Gene

IDBG-105810 (ELF3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10391676, ECO:0000269PubMed:15169914, ECO:0000269PubMed:17060315}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00237, ECO:0000269PubMed:10391676, ECO:0000269PubMed:15169914, ECO:0000269PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269PubMed:10391676, ECO:0000269PubMed:15169914, ECO:0000269PubMed:17060315}.

Disease Associations

Tissue Specificity

Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. {ECO:0000269PubMed:9129154, ECO:0000269PubMed:9234700, ECO:0000269PubMed:9336459, ECO:0000269PubMed:9395241}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	31 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001824	blastocyst development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007275	multicellular organismal development
GO:0008544	epidermis development
GO:0009653	anatomical structure morphogenesis
GO:0030198	extracellular matrix organization
GO:0030855	epithelial cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060056	mammary gland involution