InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN7

Summary

InnateDB Protein

IDBP-105831.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN7

Protein Name

protein tyrosine phosphatase, non-receptor type 7

Synonyms

BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI;

Species

Homo sapiens

Ensembl Protein

ENSP00000356248

InnateDB Gene

IDBG-105825 (PTPN7)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269PubMed:10206983, ECO:0000269PubMed:10559944, ECO:0000269PubMed:10702794, ECO:0000269PubMed:1510684, ECO:0000269PubMed:1530918, ECO:0000269PubMed:9624114}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14613483}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed exclusively in thymus and spleen. {ECO:0000269PubMed:1510684, ECO:0000269PubMed:1530918}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008356 Protein-tyrosine phosphatase, KIM-containing
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700
PR01778

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt