Version 5.4
| Homo sapiens Gene: PTPN7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105825.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PTPN7 | ||||||||||||||||||
| Gene Name | protein tyrosine phosphatase, non-receptor type 7 | ||||||||||||||||||
| Synonyms | BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000143851 | ||||||||||||||||||
| Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:202147013-202161588 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q32.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
TSLP pathway
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| REACTOME | |||||||||||||||||||
| KEGG |
MAPK signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Downstream signaling in naïve CD8+ T cells
Ras signaling in the CD4+ TCR pathway
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | C9JBA9 F8WF66 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 5778 | ||||||||||||||||||
| UniGene | Hs.402773 Hs.733059 Hs.740150 | ||||||||||||||||||
| RefSeq | NM_001199797 NM_002832 NM_080588 | ||||||||||||||||||
| HUGO | HGNC:9659 | ||||||||||||||||||
| OMIM | 176889 | ||||||||||||||||||
| CCDS | CCDS1422 CCDS1423 | ||||||||||||||||||
| HPRD | 01480 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL592300 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 5778 | ||||||||||||||||||