InnateDB Protein
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IDBP-105865.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYT2
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Protein Name
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synaptotagmin II
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356236
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InnateDB Gene
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IDBG-105861 (SYT2)
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Protein Structure
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Function |
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Synaptic vesicles and chromaffin granules. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
IPR001565
Synaptotagmin
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PFAM |
PF00168
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PRINTS |
PR00360
PR00399
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N9I0
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PhosphoSite |
PhosphoSite-Q8N9I0
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TrEMBL |
A0A024R9B3
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UniProt Splice Variant |
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Entrez Gene |
127833
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UniGene |
Hs.25422
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RefSeq |
NP_001129976
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HUGO |
HGNC:11510
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OMIM |
600104
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CCDS |
CCDS1427
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HPRD |
02520
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IMGT |
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EMBL |
AK090672
AK094430
BC100814
BC100815
BC100817
CH471067
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GenPept |
AAI00815
AAI00816
AAI00818
BAC03500
BAC04354
EAW91429
EAW91430
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