Version 5.4
Homo sapiens Gene: SYT2
Summary
InnateDB Gene IDBG-105861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT2
Gene Name synaptotagmin II
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143858
Encoded Proteins
IDBP-105863
synaptotagmin II
IDBP-105865
synaptotagmin II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202590596-202710417
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367268 ENSP00000356237
ENST00000367267 ENSP00000356236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0042584 chromaffin granule membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026452
View Gene Order
ENSBTAG00000047648
Not yet available
Pathways
NETPATH
REACTOME
REACT_11184
Neurotoxicity of clostridium toxins pathway
REACT_200782
Toxicity of botulinum toxin type B (BoNT/B) pathway
REACT_228211
Uptake and actions of bacterial toxins pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8N9I0
TrEMBL A0A024R9B3
UniProt Splice Variant
Entrez Gene 127833
UniGene Hs.25422
RefSeq NM_001136504 NM_177402
HUGO HGNC:11510
OMIM 600104
CCDS CCDS1427
HPRD
IMGT
EMBL AK090672 AK094430 BC100814 BC100815 BC100817 CH471067
GenPept AAI00815 AAI00816 AAI00818 BAC03500 BAC04354 EAW91429 EAW91430
RNA Seq Atlas 127833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca