InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM5B

Summary

InnateDB Protein

IDBP-105872.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM5B

Protein Name

lysine (K)-specific demethylase 5B

Synonyms

CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000356233

InnateDB Gene

IDBG-105868 (KDM5B)

Protein Structure

UniProt Annotation

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. {ECO:0000269PubMed:12657635, ECO:0000269PubMed:16645588, ECO:0000269PubMed:17320161, ECO:0000269PubMed:17363312}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000255PROSITE-ProRule:PRU00537, ECO:0000269PubMed:10336460, ECO:0000269PubMed:12237901}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269PubMed:10336460, ECO:0000269PubMed:10616211, ECO:0000269PubMed:10878660, ECO:0000269PubMed:12237901, ECO:0000269PubMed:15803180}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	75 [view]
Protein-DNA	22 [view]
Protein-RNA	1 [view]
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0034720	histone H3-K4 demethylation
GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001606 ARID/BRIGHT DNA-binding domain
IPR001965 Zinc finger, PHD-type
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR004198 Zinc finger, C5HC2-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR013637 Lysine-specific demethylase-like domain
IPR019787 Zinc finger, PHD-finger

PFAM