Version 5.4
Homo sapiens Protein: ADORA1
Summary
InnateDB Protein IDBP-105923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA1
Protein Name adenosine A1 receptor
Synonyms RDC7;
Species Homo sapiens
Ensembl Protein ENSP00000308549
InnateDB Gene IDBG-105921 (ADORA1)
Protein Structure
UniProt Annotation
Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001068 Adenosine A1 receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00552
PR00424
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30542
PhosphoSite PhosphoSite-P30542
TrEMBL
UniProt Splice Variant
Entrez Gene 134
UniGene Hs.77867
RefSeq XP_005244956
HUGO HGNC:262
OMIM 102775
CCDS CCDS1434
HPRD 00042
IMGT
EMBL AB004662 AC105940 AK127752 AK289928 AY136746 BC026340 BT019854 CH471067 CR541749 EF057066 L22214 S45235 S56143 X68485
GenPept AAA17544 AAB23388 AAB25533 AAH26340 AAN01272 AAV38657 ABO25743 BAA20433 BAF82617 BAG54566 CAA48503 CAG46549 EAW91465

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca