InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADORA1

Summary

InnateDB Gene

IDBG-105921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA1

Gene Name

adenosine A1 receptor

Synonyms

RDC7

Species

Homo sapiens

Ensembl Gene

ENSG00000163485

Encoded Proteins

IDBP-105923

adenosine A1 receptor

IDBP-105925

adenosine A1 receptor

IDBP-105927

adenosine A1 receptor

IDBP-105929

adenosine A1 receptor

IDBP-813780

adenosine A1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5\' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:203090654-203167405

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000309502	ENSP00000308549
ENST00000367236	ENSP00000356205
ENST00000367235	ENSP00000356204
ENST00000337894	ENSP00000338435
ENST00000464019
ENST00000472535
ENST00000467253
ENST00000618295	ENSP00000483953

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0001664	G-protein coupled receptor binding
GO:0001883	purine nucleoside binding
GO:0004629	phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0032795	heterotrimeric G-protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001659	temperature homeostasis
GO:0001666	response to hypoxia
GO:0001973	adenosine receptor signaling pathway
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0002674	negative regulation of acute inflammatory response
GO:0002686	negative regulation of leukocyte migration
GO:0002793	positive regulation of peptide secretion
GO:0003093	regulation of glomerular filtration
GO:0006612	protein targeting to membrane
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0014050	negative regulation of glutamate secretion
GO:0016042	lipid catabolic process
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032244	positive regulation of nucleoside transport
GO:0032900	negative regulation of neurotrophin production
GO:0035307	positive regulation of protein dephosphorylation
GO:0035814	negative regulation of renal sodium excretion
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
GO:0042323	negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0043066	negative regulation of apoptotic process
GO:0043268	positive regulation of potassium ion transport
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0045822	negative regulation of heart contraction
GO:0045908	negative regulation of vasodilation
GO:0046888	negative regulation of hormone secretion
GO:0048167	regulation of synaptic plasticity
GO:0050728	negative regulation of inflammatory response
GO:0050890	cognition
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050995	negative regulation of lipid catabolic process
GO:0051930	regulation of sensory perception of pain
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0055117	regulation of cardiac muscle contraction
GO:0055118	negative regulation of cardiac muscle contraction
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060087	relaxation of vascular smooth muscle
GO:0070256	negative regulation of mucus secretion
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0012505	endomembrane system
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030425	dendrite
GO:0030673	axolemma
GO:0032279	asymmetric synapse
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0048786	presynaptic active zone