InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADORA1

Summary

InnateDB Protein

IDBP-105929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA1

Protein Name

adenosine A1 receptor

Synonyms

RDC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000338435

InnateDB Gene

IDBG-105921 (ADORA1)

Protein Structure

UniProt Annotation

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001068 Adenosine A1 receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00552
PR00424

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30542