InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHI3L1

Summary

InnateDB Protein

IDBP-105935.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHI3L1

Protein Name

chitinase 3-like 1 (cartilage glycoprotein-39)

Synonyms

ASRT7; CGP-39; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40;

Species

Homo sapiens

Ensembl Protein

ENSP00000255409

InnateDB Gene

IDBG-105933 (CHI3L1)

Protein Structure

UniProt Annotation

Function

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269PubMed:16472595, ECO:0000269PubMed:19414556, ECO:0000269PubMed:20558631, ECO:0000269PubMed:9492324}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269PubMed:16472595, ECO:0000269PubMed:9492324}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0005201	extracellular matrix structural constituent
GO:0008061	chitin binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009612	response to mechanical stimulus
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0030324	lung development
GO:0034612	response to tumor necrosis factor
GO:0045766	positive regulation of angiogenesis
GO:0051216	cartilage development
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070555	response to interleukin-1
GO:0070741	response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0072606	interleukin-8 secretion

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P36222