Version 5.4
Homo sapiens Gene: CHI3L1
Summary
InnateDB Gene IDBG-105933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHI3L1
Gene Name chitinase 3-like 1 (cartilage glycoprotein-39)
Synonyms ASRT7; CGP-39; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40
Species Homo sapiens
Ensembl Gene ENSG00000133048
Encoded Proteins
IDBP-105935
chitinase 3-like 1 (cartilage glycoprotein-39)
IDBP-295638
chitinase 3-like 1 (cartilage glycoprotein-39)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203178931-203186749
Strand Reverse strand
Band q32.1
Transcripts
ENST00000255409 ENSP00000255409
ENST00000404436 ENSP00000385350
ENST00000473185
ENST00000478742
ENST00000472064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0005201 extracellular matrix structural constituent
GO:0008061 chitin binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006032 chitin catabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0009612 response to mechanical stimulus
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0030324 lung development
GO:0034612 response to tumor necrosis factor
GO:0045766 positive regulation of angiogenesis
GO:0051216 cartilage development
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0070741 response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0072606 interleukin-8 secretion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064246
View Gene Order
ENSBTAG00000018223
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.382202
RefSeq NM_001276
HUGO
OMIM
CCDS CCDS1435
HPRD 03314
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca