InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3C2B

Summary

InnateDB Protein

IDBP-106049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C2B

Protein Name

phosphoinositide-3-kinase, class 2, beta polypeptide

Synonyms

C2-PI3K;

Species

Homo sapiens

Ensembl Protein

ENSP00000356155

InnateDB Gene

IDBG-106047 (PIK3C2B)

Protein Structure

UniProt Annotation

Function

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269PubMed:10805725}.

Subcellular Localization

Microsome {ECO:0000269PubMed:14563213}. Cell membrane {ECO:0000269PubMed:14563213}. Cytoplasm, cytosol {ECO:0000269PubMed:14563213}. Nucleus {ECO:0000269PubMed:14563213}. Endoplasmic reticulum {ECO:0000269PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

Disease Associations

Tissue Specificity

Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. {ECO:0000269PubMed:14563213, ECO:0000269PubMed:9144573}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001727	lipid kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008150	biological_process
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043491	protein kinase B signaling
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0030139	endocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00794
PF00454
PF00613
PF00787
PF00792

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00144
SM00146
SM00145
SM00312
SM00142

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt