Version 5.4
Homo sapiens Gene: PIK3C2B
Summary
InnateDB Gene IDBG-106047.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3C2B
Gene Name phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Synonyms C2-PI3K
Species Homo sapiens
Ensembl Gene ENSG00000133056
Encoded Proteins
IDBP-106049
phosphoinositide-3-kinase, class 2, beta polypeptide
IDBP-106053
phosphoinositide-3-kinase, class 2, beta polypeptide
IDBP-389933
phosphoinositide-3-kinase, class 2, beta polypeptide
IDBP-389935
phosphoinositide-3-kinase, class 2, beta polypeptide
IDBP-389936
phosphoinositide-3-kinase, class 2, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:204422628-204494724
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367187 ENSP00000356155
ENST00000367184 ENSP00000356152
ENST00000424712 ENSP00000400561
ENST00000415899 ENSP00000401795
ENST00000429009 ENSP00000409554
ENST00000462752
ENST00000479079
ENST00000496872
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001727 lipid kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008150 biological_process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043491 protein kinase B signaling
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0030139 endocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026447
View Gene Order
ENSBTAG00000024633
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt O00750
TrEMBL A2RUF7 Q4LE65 Q5SW97 Q5SW98
UniProt Splice Variant
Entrez Gene 5287
UniGene Hs.497487
RefSeq NM_002646 XM_005245257 XM_006711384 XM_005245258
HUGO HGNC:8972
OMIM 602838
CCDS CCDS1446
HPRD 04160
IMGT
EMBL AB210006 AL606489 BC132876 BC136645 CH471067 EU332863 JX512455 Y11312 Y13892
GenPept AAI32877 AAI36646 ABY87552 AGC09602 BAE06088 CAA72168 CAA74194 CAI16572 EAW91514
RNA Seq Atlas 5287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca