InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BST1

Summary

InnateDB Protein

IDBP-10618.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BST1

Protein Name

bone marrow stromal cell antigen 1

Synonyms

CD157;

Species

Homo sapiens

Ensembl Protein

ENSP00000265016

InnateDB Gene

IDBG-10614 (BST1)

Protein Structure

UniProt Annotation

Function

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. {ECO:0000269PubMed:11866528}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003953	NAD+ nucleosidase activity
GO:0016740	transferase activity
GO:0050135	NAD(P)+ nucleosidase activity

Biological Process

GO:0006959	humoral immune response
GO:0007275	multicellular organismal development
GO:0008152	metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003193 ADP-ribosyl cyclase (CD38/157)

PFAM

PF02267

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q10588

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC114744 AK312497 BC012095 BT019502 CH471069 D21878

GenPept

AAH12095 AAV38309 AAY40930 BAA04885 BAG35399 EAW92744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca