InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A9

Summary

InnateDB Protein

IDBP-106191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A9

Protein Name

solute carrier family 26, member 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356103

InnateDB Gene

IDBG-106189 (SLC26A9)

Protein Structure

UniProt Annotation

Function

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate. {ECO:0000269PubMed:11834742, ECO:0000269PubMed:15800055}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate. {ECO:0000269PubMed:11834742}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0051117	ATPase binding

Biological Process

GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0010628	positive regulation of gene expression
GO:0015701	bicarbonate transport
GO:0055085	transmembrane transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome