Version 5.4
Homo sapiens Gene: SLC26A9
Summary
InnateDB Gene IDBG-106189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A9
Gene Name solute carrier family 26, member 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174502
Encoded Proteins
IDBP-106191
solute carrier family 26, member 9
IDBP-106193
solute carrier family 26, member 9
IDBP-106195
solute carrier family 26, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:205913048-205943460
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367135 ENSP00000356103
ENST00000340781 ENSP00000341682
ENST00000367134 ENSP00000356102
ENST00000491127
ENST00000461505
ENST00000469392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006885 regulation of pH
GO:0008272 sulfate transport
GO:0010628 positive regulation of gene expression
GO:0015701 bicarbonate transport
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042268
View Gene Order
ENSBTAG00000001382
Not yet available
Pathways
NETPATH
REACTOME
REACT_19357
Multifunctional anion exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7LBE3
TrEMBL
UniProt Splice Variant
Entrez Gene 115019
UniGene Hs.164073
RefSeq NM_052934 NM_134325 XM_006711144
HUGO HGNC:14469
OMIM 608481
CCDS CCDS30989 CCDS30990
HPRD 12242
IMGT
EMBL AF314958 AF331525 AL713965 BC136538 BC151208 CH471067
GenPept AAI36539 AAI51209 AAK95667 AAL26867 CAI22384 EAW91587 EAW91588
RNA Seq Atlas 115019

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca