InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2D

Summary

InnateDB Protein

IDBP-106251.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2D

Protein Name

eukaryotic translation initiation factor 2D

Synonyms

HCA56; LGTN;

Species

Homo sapiens

Ensembl Protein

ENSP00000356081

InnateDB Gene

IDBG-106247 (EIF2D)

Protein Structure

UniProt Annotation

Function

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P- site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269PubMed:20566627, ECO:0000269PubMed:20713520}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20566627}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0002192	IRES-dependent translational initiation
GO:0006413	translational initiation
GO:0006886	intracellular protein transport
GO:0032790	ribosome disassembly