Version 5.4
Homo sapiens Gene: EIF2D
Summary
InnateDB Gene IDBG-106247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2D
Gene Name eukaryotic translation initiation factor 2D
Synonyms HCA56; LGTN
Species Homo sapiens
Ensembl Gene ENSG00000143486
Encoded Proteins
IDBP-106249
eukaryotic translation initiation factor 2D
IDBP-106251
eukaryotic translation initiation factor 2D
IDBP-389965
eukaryotic translation initiation factor 2D
IDBP-812762
eukaryotic translation initiation factor 2D
IDBP-812792
eukaryotic translation initiation factor 2D
IDBP-812791
eukaryotic translation initiation factor 2D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:206571292-206612463
Strand Reverse strand
Band q32.1
Transcripts
ENST00000271764 ENSP00000271764
ENST00000367114 ENSP00000356081
ENST00000437518 ENSP00000394685
ENST00000472709 ENSP00000484299
ENST00000468891
ENST00000484492 ENSP00000479327
ENST00000461334
ENST00000474408
ENST00000617960
ENST00000613435 ENSP00000484590
ENST00000620382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002192 IRES-dependent translational initiation
GO:0006413 translational initiation
GO:0006886 intracellular protein transport
GO:0032790 ribosome disassembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0022627 cytosolic small ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026427
View Gene Order
ENSBTAG00000010432
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001201478 NM_006893
HUGO
OMIM
CCDS CCDS1465 CCDS55680
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca