Version 5.4
Homo sapiens Protein: FAIM3
Summary
InnateDB Protein IDBP-106294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAIM3
Protein Name Fas apoptotic inhibitory molecule 3
Synonyms FCMR; TOSO;
Species Homo sapiens
Ensembl Protein ENSP00000356058
InnateDB Gene IDBG-106292 (FAIM3)
Protein Structure
UniProt Annotation
Function May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. {ECO:0000269PubMed:9586636}.
Subcellular Localization Isoform 1: Membrane; Single-pass membrane protein.Isoform 3: Secreted. Note=Detected in the serum.
Disease Associations
Tissue Specificity Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. {ECO:0000269PubMed:21908424, ECO:0000269PubMed:9586636}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002376 immune system process
GO:0006968 cellular defense response
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07686
PF00047
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60667
PhosphoSite PhosphoSite-O60667
TrEMBL E9PN59
UniProt Splice Variant
Entrez Gene 9214
UniGene Hs.58831
RefSeq NP_005440
HUGO HGNC:14315
OMIM 606015
CCDS CCDS1473
HPRD 09349
IMGT
EMBL AC098935 AF057557 AK292007 AK301187 AK316336 BC006401 BT006797 CH471100 HM480394
GenPept AAC18830 AAH06401 AAP35443 ADK11426 BAF84696 BAH13426 BAH14707 EAW93517

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca