InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC8A3

Summary

InnateDB Protein

IDBP-10631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC8A3

Protein Name

solute carrier family 8 (sodium/calcium exchanger), member 3

Synonyms

NCX3;

Species

Homo sapiens

Ensembl Protein

ENSP00000370669

InnateDB Gene

IDBG-10629 (SLC8A3)

Protein Structure

UniProt Annotation

Function

Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269PubMed:15777725}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005516	calmodulin binding
GO:0015368	calcium:cation antiporter activity

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006816	calcium ion transport
GO:0007154	cell communication
GO:0007596	blood coagulation
GO:0021537	telencephalon development
GO:0030001	metal ion transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0060402	calcium ion transport into cytosol
GO:0071320	cellular response to cAMP
GO:1990034	calcium ion export from cell
GO:1990035	calcium ion import into cell

Cellular Component

GO:0005739	mitochondrion
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042383	sarcolemma
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine