Version 5.4
Homo sapiens Gene: SLC8A3
Summary
InnateDB Gene IDBG-10629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC8A3
Gene Name solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms NCX3
Species Homo sapiens
Ensembl Gene ENSG00000100678
Encoded Proteins
IDBP-10631
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-10633
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-10635
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-10639
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-241775
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-602558
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-584194
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-594664
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-603087
solute carrier family 8 (sodium/calcium exchanger), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70044217-70189070
Strand Reverse strand
Band q24.2
Transcripts
ENST00000381269 ENSP00000370669
ENST00000357887 ENSP00000350560
ENST00000216568 ENSP00000216568
ENST00000356921 ENSP00000349392
ENST00000394330 ENSP00000377863
ENST00000494208 ENSP00000436332
ENST00000534137 ENSP00000436688
ENST00000528359 ENSP00000433531
ENST00000533541 ENSP00000437103
ENST00000533899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
GO:0005516 calmodulin binding
GO:0015368 calcium:cation antiporter activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0007596 blood coagulation
GO:0021537 telencephalon development
GO:0030001 metal ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0060402 calcium ion transport into cytosol
GO:0071320 cellular response to cAMP
GO:1990034 calcium ion export from cell
GO:1990035 calcium ion import into cell
Cellular Component
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079055
View Gene Order
ENSBTAG00000027080
Not yet available
Pathways
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt P57103
TrEMBL Q86TQ9
UniProt Splice Variant
Entrez Gene 6547
UniGene Hs.337696 Hs.715967
RefSeq NM_001130417 NM_033262 NM_058240 NM_182932 NM_182936 NM_183002 XM_005268017 XM_005268018 XM_006720239 XM_006720240
HUGO HGNC:11070
OMIM 607991
CCDS CCDS9799 CCDS35498 CCDS41967 CCDS45131 CCDS53904 CCDS9800
HPRD 09723
IMGT
EMBL AF508982 AF510501 AF510502 AF510503 AJ304852 AJ304853 AJ745101 AJ745102 AL135747 AL160191 BC142969 BX248763 CH471061 X93017
GenPept AAI42970 AAM90955 AAN60790 AAN60791 AAN60792 CAC40984 CAC40985 CAD66570 CAG33739 CAG33740 EAW81019 EAW81021 EAW81026
RNA Seq Atlas 6547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca