Homo sapiens Protein: PLXNA4 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-106412.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | PLXNA4 | ||||||||||
Protein Name | plexin A4 | ||||||||||
Synonyms | |||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Protein | ENSP00000323194 | ||||||||||
InnateDB Gene | IDBG-281690 (PLXNA4) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR001627
Sema domain IPR002165 Plexin IPR002909 IPT domain IPR008936 Rho GTPase activation protein IPR013548 Plexin, cytoplasmic RasGAP domain IPR014756 Immunoglobulin E-set IPR016201 Plexin-like fold |
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PFAM |
PF01403
PF01437 PF01833 PF08337 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00630
SM00429 SM00423 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9HCM2 | ||||||||||
PhosphoSite | PhosphoSite-Q9HCM2 | ||||||||||
TrEMBL | A0A024R7A6 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 91584 | ||||||||||
UniGene | Hs.601190 | ||||||||||
RefSeq | NP_065962 | ||||||||||
HUGO | HGNC:9102 | ||||||||||
OMIM | 604280 | ||||||||||
CCDS | CCDS43646 | ||||||||||
HPRD | 10901 | ||||||||||
IMGT | |||||||||||
EMBL | AB046770 AC009364 AC009365 AC009785 AC011625 AC018643 AC026239 AK095606 AK123428 AL137352 AL834504 AY358850 BC028744 CH236950 CH471070 | ||||||||||
GenPept | AAH28744 AAQ89209 BAB13376 BAC04587 BAC85615 CAB70707 CAD39161 EAL24076 EAW83793 EAW83794 EAW83795 | ||||||||||