Version 5.4
Homo sapiens Gene: PLXNA4
Summary
InnateDB Gene IDBG-281690.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNA4
Gene Name plexin A4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000221866
Encoded Proteins
IDBP-41861
plexin A4
IDBP-41880
plexin A4
IDBP-106412
plexin A4
IDBP-386396
plexin A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21098092
PLXNA4 is a receptor protein and its expression in macrophages is required for optimal cytokine production upon TLR stimulation. PLXNA4 is a crucial component of sepsis-induced cytokine storm by activating RAC1, MAPK8 and NFKB.
InnateDB Annotation from Orthologs
Summary
PMID 21098092
[Mus musculus] Plxna4 is a receptor protein and its expression in macrophages is required for optimal cytokine production upon Tlr stimulation. Plxna4 is a crucial component of sepsis-induced cytokine storm by activating Rac1, Mapk8 and Nfkb.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:132123332-132648688
Strand Reverse strand
Band q32.3
Transcripts
ENST00000359827 ENSP00000352882
ENST00000378539 ENSP00000367800
ENST00000321063 ENSP00000323194
ENST00000423507 ENSP00000392772
ENST00000496550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008045 motor neuron axon guidance
GO:0021602 cranial nerve morphogenesis
GO:0021610 facial nerve morphogenesis
GO:0021612 facial nerve structural organization
GO:0021615 glossopharyngeal nerve morphogenesis
GO:0021636 trigeminal nerve morphogenesis
GO:0021637 trigeminal nerve structural organization
GO:0021644 vagus nerve morphogenesis
GO:0021784 postganglionic parasympathetic nervous system development
GO:0021785 branchiomotor neuron axon guidance
GO:0021793 chemorepulsion of branchiomotor axon
GO:0021960 anterior commissure morphogenesis
GO:0045087 innate immune response (InnateDB)
GO:0048485 sympathetic nervous system development
GO:0048812 neuron projection morphogenesis
GO:0048841 regulation of axon extension involved in axon guidance
GO:0050923 regulation of negative chemotaxis
GO:0071526 semaphorin-plexin signaling pathway
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
Cellular Component
GO:0002116 semaphorin receptor complex
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029765
View Gene Order
ENSBTAG00000014543
Not yet available
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19200
Other semaphorin interactions pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511454 Hs.601190
RefSeq NM_001105543 NM_020911 NM_181775 XM_005250686 XM_005250687 XM_006716171
HUGO
OMIM
CCDS CCDS43646 CCDS43647 CCDS5826
HPRD 10901
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca