InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPGAT1

Summary

InnateDB Protein

IDBP-106525.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPGAT1

Protein Name

lysophosphatidylglycerol acyltransferase 1

Synonyms

FAM34A; FAM34A1; NET8;

Species

Homo sapiens

Ensembl Protein

ENSP00000355963

InnateDB Gene

IDBG-106521 (LPGAT1)

Protein Structure

UniProt Annotation

Function

Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. {ECO:0000269PubMed:15485873}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15485873}; Multi-pass membrane protein {ECO:0000269PubMed:15485873}.

Disease Associations

Tissue Specificity

Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. {ECO:0000269PubMed:15485873}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process