InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BPNT1

Summary

InnateDB Protein

IDBP-106732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPNT1

Protein Name

3'(2'), 5'-bisphosphate nucleotidase 1

Synonyms

HEL20; PIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000318852

InnateDB Gene

IDBG-106730 (BPNT1)

Protein Structure

UniProt Annotation

Function

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. {ECO:0000269PubMed:10224133}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle. {ECO:0000269PubMed:10224133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007399	nervous system development
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process