InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BPNT1

Summary

InnateDB Gene

IDBG-106730.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPNT1

Gene Name

3'(2'), 5'-bisphosphate nucleotidase 1

Synonyms

HEL20; PIP

Species

Homo sapiens

Ensembl Gene

ENSG00000162813

Encoded Proteins

IDBP-106732

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-106734

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-390026

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-598658

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-600447

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-591127

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-589119

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-593622

3'(2'), 5'-bisphosphate nucleotidase 1

IDBP-586284

3'(2'), 5'-bisphosphate nucleotidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92%% identical to mouse BPntase. BPntase\'s physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:220057482-220090462

Strand

Reverse strand

Band

q41

Transcripts

ENST00000322067	ENSP00000318852
ENST00000354807	ENSP00000346862
ENST00000414869	ENSP00000410348
ENST00000469520	ENSP00000446828
ENST00000480959	ENSP00000448740
ENST00000498237	ENSP00000449883
ENST00000498791	ENSP00000446850
ENST00000482136
ENST00000463953	ENSP00000446953
ENST00000548668
ENST00000544404	ENSP00000444398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity
GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007399	nervous system development
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026617

View Gene Order

ENSBTAG00000004064

Not yet available

Pathways

NETPATH

REACTOME

REACT_6913

Cytosolic sulfonation of small molecules pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00920

Sulfur metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.406134

RefSeq

NM_001286149 NM_001286150 NM_001286151 NM_006085 XM_005273000

HUGO

OMIM

CCDS

CCDS41469 CCDS65787 CCDS65788

HPRD

06814

IMGT

EMBL

GenPept

RNA Seq Atlas