InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARK1

Summary

InnateDB Protein

IDBP-106757.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARK1

Protein Name

MAP/microtubule affinity-regulating kinase 1

Synonyms

MARK; Par-1c; Par1c;

Species

Homo sapiens

Ensembl Protein

ENSP00000355884

InnateDB Gene

IDBG-106753 (MARK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269PubMed:11433294, ECO:0000269PubMed:17573348}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21145462}; Peripheral membrane protein {ECO:0000269PubMed:21145462}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Appears to localize to an intracellular network. {ECO:0000250}.

Disease Associations

Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.

Tissue Specificity

Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. {ECO:0000269PubMed:9108484}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0001786	phosphatidylserine binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050321	tau-protein kinase activity
GO:0070300	phosphatidic acid binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0016055	Wnt signaling pathway
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain

PFAM

PF00069
PF07714
PF02149

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt