InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF1A

Summary

InnateDB Protein

IDBP-106802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1A

Protein Name

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

Synonyms

MGC:17061; RAFI48; SL1; TAFI48;

Species

Homo sapiens

Ensembl Protein

ENSP00000327072

InnateDB Gene

IDBG-106798 (TAF1A)

Protein Structure

UniProt Annotation

Function

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269PubMed:15970593, ECO:0000269PubMed:7801123}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0010467	gene expression

Cellular Component

GO:0000120	RNA polymerase I transcription factor complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0015630	microtubule cytoskeleton
GO:0043231	intracellular membrane-bounded organelle