InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF1A

Summary

InnateDB Gene

IDBG-106798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1A

Gene Name

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

Synonyms

MGC:17061; RAFI48; SL1; TAFI48

Species

Homo sapiens

Ensembl Gene

ENSG00000143498

Encoded Proteins

IDBP-106800

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

IDBP-106802

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

IDBP-106804

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

IDBP-246791

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:222557902-222589933

Strand

Reverse strand

Band

q41

Transcripts

ENST00000366890	ENSP00000355856
ENST00000352967	ENSP00000327072
ENST00000350027	ENSP00000339976
ENST00000391883	ENSP00000375755
ENST00000487009
ENST00000480065
ENST00000465263

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0010467	gene expression

Cellular Component

GO:0000120	RNA polymerase I transcription factor complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0015630	microtubule cytoskeleton
GO:0043231	intracellular membrane-bounded organelle